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Invitrogen™ CHMP4B Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5100092
This item is not returnable.
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Description
Antibody detects endogenous levels of total CHMP4B.
CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
Specifications
| CHMP4B | |
| Polyclonal | |
| Unconjugated | |
| CHMP4B | |
| 2010012F05Rik; C20orf178; C76846; charged multivesicular body protein 4b; CHMP4A; CHMP4B; chromatin modifying protein 4B; chromatin-modifying protein 4b; CTPP3; CTRCT31; dJ553F4.4; hSnf7-2; hVps32-2; RGD1309846; RGD1565889; Shax1; SNF7; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; Snf7-2; Vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2; VPS32B | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 100359642, 128866, 75608 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9D8B3, Q9H444 | |
| CHMP4B | |
| A synthesized peptide derived from human CHMP4B(Accession Q9H444), corresponding to amino acid residues M1-E50. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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