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Invitrogen™ CMG2 Polyclonal Antibody
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Product Code. 11347273
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Quantity:
100 μg
Unit Size:
100µg
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11347273 100 μg 100µg
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Product Code. 11347273 Supplier Invitrogen™ Supplier No. PA519295

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Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine and canine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CMG2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene ANTXR2
Gene Accession No. P58335
Gene Alias 2310046B19Rik; anthrax toxin receptor 2; ANTXR cell adhesion molecule 2; ANTXR cell adhesion molecule 2; anthrax toxin receptor 2; ANTXR2; AW561899; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856
Gene Symbols ANTXR2
Host Species Goat
Immunogen Synthetic peptide sequence (HEGLKLANEQIQK) corresponding to the internal amino acids of ANTXR2 (aa 121-134).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 118429
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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