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Invitrogen™ CMYA5 Polyclonal Antibody

Description
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FISEVSREDY GKKEISGDSE EMNINSVVTS ADGENLEIQS YSLIGEKLVM EEAKTIVPPH VTDSKRVQKP AIAPPSK Highest antigen sequence indentity to the following orthologs: Rat - 48%, Mouse - 40%.
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
Specifications
Specifications
| Antigen | CMYA5 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.3 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | CMYA5 |
| Gene Accession No. | Q8N3K9 |
| Gene Alias | 2310076E16Rik; 2310076E21Rik; AA420382; AI504003; C5orf10; cardiomyopathy associated 5; cardiomyopathy-associated protein 5; CMYA5; DTNBP2; Dystrobrevin-binding protein 2; genethonin-3; heart and skeletal muscle-specific and sprouty domain-containing; myospryn; SPRY domain-containing protein 2; SPRYD2; sr553; Srfsd; stretch response protein 553; stretch-response protein 553; stretch-responsive fibronectin protein type 3; Tims; TRIM76; TRIM-like protein; tripartite motif-containing 76; tripartite motif-containing protein 76 |
| Gene Symbols | CMYA5 |
| Show More |
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