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CNOT4 Monoclonal Antibody (OTI3B8), TrueMAB™, OriGene

Product Code. 17567432
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100 μL
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17567432 100 μL 100µL
17587432 30 μL 30µL
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Product Code. 17567432 Supplier Origene Technologies Supplier No. TA800047

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Description

Mouse Monoclonal Antibody

CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.

Specifications

Antigen CNOT4
Applications Western Blot
Classification Monoclonal
Clone OTI3B8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CNOT4
Gene Accession No. O95628
Gene Alias CLONE243, NOT4, NOT4H
Gene Symbols CNOT4
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 190-455 of human CNOT4 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4850
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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