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Invitrogen™ Complement C4b/C4c Polyclonal Antibody, FITC
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Product Code. 11585853
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500 μL
Unit Size:
500µL
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11585853 500 μL 500µL
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Product Code. 11585853 Supplier Invitrogen™ Supplier No. PA128407

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Description

Rabbit Polyclonal Antibody

PA1-28407 detects C4c / C4b from human samples. Antigen retrieval for IHC (P): Proteinase K 30 min at 37°C.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement C4b/C4c
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate FITC
Formulation PBS with 0.09% sodium azide
Gene C4B
Gene Accession No. P0C0L5
Gene Alias Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A; C4a anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; C4S; CH; Chido form of C4; CO4; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement component 4B (Chido blood group); CPAMD2; CPAMD3; DAMC-258G8.6; MGC164979; RG
Gene Symbols C4B
Host Species Rabbit
Immunogen C4c complement isolated from complement activated human serum.
Purification Method IgG fraction
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100293534, 721
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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