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Invitrogen™ Complement C4c Monoclonal Antibody (10-12)
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Product Code. 16392394
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Quantity:
100 μg
Unit Size:
100µg
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16392394 100 μg 100µg
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Product Code. 16392394 Supplier Invitrogen™ Supplier No. MA528087

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Description

Mouse Monoclonal Antibody

This antibody recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated.

C4B may be involved in systemic lupus erythematosus (SLE). A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variations affecting the gene represented in this entry. Interindividual copy-number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement C4c
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 10-12
Concentration 1.15 mg/mL
Conjugate Unconjugated
Formulation BBS with <0.1% sodium azide
Gene C4B
Gene Accession No. P0C0L5
Gene Alias Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A; C4a anaphylatoxin; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; CH; Chido form of C4; CO4; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement component 4B (Chido blood group); CPAMD2; CPAMD3
Gene Symbols C4B
Host Species Mouse
Immunogen Purified human C4c.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100293534, 721
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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