Invitrogen™ CPAMD8 Polyclonal Antibody

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human placenta tissue, human T-47D whole cell, human U2OS whole cell, human K562 whole cell, human THP-1 whole cell, monkey COS-7 whole cell. IHC: human lung cancer tissue, human mammary cancer tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The CPAMD8 gene, known as C3 and pregnancy zone protein-like alpha-2-macroglobulin domain-containing 8, is involved in the development of ocular tissues. It has been linked to anterior segment dysgenesis (ASD) and congenital glaucoma, indicating its critical role in eye development. CPAMD8 functions primarily within the non-pigmented epithelium and might participate in cellular communication and structural integrity during the differentiation of retinal organoids. Loss-of-function mutations in CPAMD8 disrupt normal eye formation, leading to various ocular disorders. Recent advancements, such as the establishment of CPAMD8-GFP reporter human embryonic stem cell lines, enable real-time monitoring of its expression, thereby facilitating exploration of its biological functions in retinal differentiation processes. Bioinformatic evaluations and CRISPR/Cas9 technology have provided insights into CPAMD8's role in eye development, with gene editing approaches helping delineate its involvement in ocular health and disease.