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Tocris Bioscience™ CRID3 sodium salt
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Product Code. 18793949
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18793949

Brand: Tocris Bioscience™ 5479/50

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994.50 EUR valid until 2025-12-16
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Description

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production

CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 50 mg
Product Type CRID3 sodium salt
Purity 98%
Molecular Weight (g/mol) 426.46

For Research Use Only

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