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Invitrogen™ CrkRS Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5117328

Product Code. 17279823

  • € 497.00 / 100µL

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Description

Description

Centrifuge briefly prior to opening.

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CrkRS
Polyclonal
Unconjugated
CDK12
1810022J16Rik; AI646528; CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cdk12; Cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; Crkrs; cyclin dependent kinase 12; cyclin-dependent kinase 12; cyclin-dependent kinase 12 isoform; D11Ertd752e; H KIAA0904; hCDK12; Kiaa0904; Pksc; Protein kinase for splicing component
Rabbit
Antigen affinity chromatography
RUO
51755, 69131
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.83 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Q14AX6, Q9NYV4
CDK12
Recombinant protein encompassing a sequence within the C-terminus region of human CrkRS. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse
Antibody
IgG
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