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CSK Recombinant Rabbit Monoclonal Antibody (5H3L21), Invitrogen™

Product Code. 16555631
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Quantity:
100 μg
Unit Size:
100µg
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16555631 100 μg 100µg
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Product Code. 16555631 Supplier Invitrogen Supplier No. 703673

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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Mouse, Pig. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CSK
Applications Western Blot
Classification Recombinant Monoclonal
Clone 5H3L21
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide, pH 7.4
Gene CSK
Gene Accession No. P41240
Gene Alias AW212630, CSK, CSK, non-receptor tyrosine kinase, C-SRC kinase, c-src tyrosine kinase, C-terminal Src kinase, MGC117393, p50CSK, protein-tyrosine kinase (CSK), protein-tyrosine kinase CYL, Protein-tyrosine kinase MPK-2, Tyrosine-protein kinase CSK
Gene Symbols CSK
Host Species Rabbit
Immunogen Protein corresponding to human CSK [aa73-aa178]
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1445
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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