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Invitrogen™ CUEDC2 Polyclonal Antibody

Product Code. 15908074
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Quantity:
100 μL
Unit Size:
100µL
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15908074 100 μL 100µL
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Product Code. 15908074 Supplier Invitrogen™ Supplier No. PA565315

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QKDELKSFILQ KYMMVDSAED QKIHRPMAPK EAPKKLIRYI DNQVVSTKGE RFKDVRNPEA EEMKATYINL KPARKYRFH Highest antigen sequence identity to the following orthologs - mouse 96%, rat 94%.

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CUEDC2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CUEDC2
Gene Accession No. Q9H467
Gene Alias 3010002G01Rik; bA18I14.5; C10orf66; CUE domain containing 2; CUE domain-containing protein 2; CUEDC2; HOYS6; Unknown (protein for MGC:128745)
Gene Symbols CUEDC2
Host Species Rabbit
Immunogen Recombinant Human CUEDC2. Recombinant protein control fragment (Product #RP-106018).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79004
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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