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Invitrogen™ Cullin 9 Polyclonal Antibody
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Product Code. 12888412
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Quantity:
100 μg
Unit Size:
100µg
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12888412 100 μg 100µg
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Product Code. 12888412 Supplier Invitrogen™ Supplier No. PA520277

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Daudi cell lysate. PA5-20277 can be used with blocking peptide PEP-0354.

The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
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Specifications

Antigen Cullin 9
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CUL9
Gene Accession No. Q80TT8, Q8IWT3
Gene Alias 1810035I07Rik; CUL9; CUL-9; cullin 9; cullin-9; H7AP1; KIAA0708; mKIAA0708; p53-associated parkin-like cytoplasmic protein; PARC; parkin-like cytoplasmic p53 binding protein; RP3-330M21.2; UbcH7-associated protein 1
Gene Symbols CUL9
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the carboxy terminus of human PARC.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23113, 78309
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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