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  5. STEMCELL Technologies Cyclic Pifithrin-Alpha (Hydrobromide)

STEMCELL Technologies Cyclic Pifithrin-Alpha (Hydrobromide)

Product Code. 17100022
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Product Code. 17100022 Supplier STEMCELL Technologies Supplier No. 72062

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Description

p53 Inhibitor

  • Cyclic Pifthrin-Alpha is a cell-permeable and reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription
  • It is a more stable and less cytotoxic analog of the non-cyclic form of pifithrin-alpha
  • Cyclic Pifithrin-Alpha has also been reported to activate the aryl hydrocarbon receptor
  • (Fernandez-Cruz et al.), Gary & Jensen, Komarov et al.)
  • Increases efficiency of reprogramming mouse embryonic fibroblasts to induced pluripotent stem cells (Liao et al.)
  • Reduces UV-induced apoptosis of mouse embryonic stem cells (Qin et al.)
  • Increases the numbers of mouse hematopoietic stem and progenitor cells in vivo and in vitro, also decreases the radiation-induced death of these cells (Leonova et al.)

Specifications

CAS 511296-88-1
Synonym Cyclic PFT-α; Cyclic Pifithrin-α; PFT-β; Pifithrin-β
Quantity 5 mg
Molecular Formula C16H16N2S · HBr
Purity ≥95%
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