Invitrogen™ CYP3A4 Polyclonal Antibody

Description

Positive test controls include: Mouse liver, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein. Immunogen sequence: EVTNFLRKSV KRMKESRLED TQKHRVDFLQ LMIDSQNSKE TESHKALSDL ELVAQSIIFI FAGYETTSSV LSFIMYELAT HPDVQQKLQE EIDAVLPNKA PPTYDTVLQM EYLDMVVNET LRLFPIAMRL ERVCKKDVEI NGMFIPKGVV VMIPSYALHR DPKYWTEPEK FLPERFSKKN KDNIDPYIYT PFGSGPRNCI GMRFALMNMK LALIRVLQNF SFKPCKETQI PLKLSLGGLL QPEKPVVLKV ESRDGTVSGA.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.