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Invitrogen™ CYP3A4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA514896
This item is not returnable.
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Description
CYP3A4 Polyclonal Antibody for Western Blot, IHC (P), Flow
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Specifications
| CYP3A4 | |
| Polyclonal | |
| Unconjugated | |
| CYP3A4 | |
| 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; cholesterol 25-hydroxylase; CP33; CP34; CYP; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; cytochrome P450 3A4; cytochrome P450 family 3 subfamily A member 4; cytochrome P450 HLp; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450-PCN1; glucocorticoid-inducible P450; HLP; MGC126680; NF-25; Nifedipine oxidase; P450; P450C3; P450-III, steroid inducible; P450PCN1; P450-PCN1; Quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase | |
| Rabbit | |
| Antigen affinity chromatography, Protein A | |
| RUO | |
| 1576 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| P08684 | |
| CYP3A4 | |
| KLH conjugated synthetic peptide between 228-255 amino acids from the central region of human CYP3A4. | |
| 200 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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