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Invitrogen™ CYP8B1 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA537088

Product Code. 15554241

  • € 518.00 / 100µL

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Description

Description

This antibody detects endogenous protein at a molecular weight of 58 kDa. Purity is >95% by SDS-PAGE.

CYP8B1 (sterol 12-alpha-hydroxylase) is a member of the cytochrome P450 superfamily of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. CYP8B1 is highly expressed in liver and is an important enzyme for bile acid synthesis. Specifically, CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol. The gene encoding human CYP8B1 maps to chromosome 3p22.1. The CYP8B1 gene encodes a 501-amino acid protein and does not contain any introns. The CYP8B1 gene promoter is transactivated by hepatocyte nuclear factor 4a. In mice, disruption of the CYP8B1 gene prevents the synthesis of cholate, which is a primary bile acid.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CYP8B1
Polyclonal
Unconjugated
CYP8B1
7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CP8B; CYP12; Cyp8b1; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450 family 8 subfamily B member 1; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1; sterol 12-alpha-hydrolase; sterol 12-alpha-hydroxylase
Rabbit
Antigen affinity chromatography
RUO
13124, 1582, 81924
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
O88962, Q9UNU6
CYP8B1
Synthetic peptide corresponding to amino acids 416-461 of human CYP8B1.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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