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Cytochrome P450 Pan Polyclonal Antibody, Invitrogen™

Product Code. 15515821
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Quantity:
100 μg
Unit Size:
100µg
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15515821 100 μg 100µg
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Product Code. 15515821 Supplier Invitrogen Supplier No. PA538907

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Description

Rabbit Polyclonal Antibody

This antibody detects Cytochrome P450 2C8, 2C9, 2C18 and 2C19.

The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP2C (CYPIIC) subfamily comprises a group of constitutively expressed genes, some phenobarbital-induced genes, and several genes associated with sex-specific expression. Originally, at least 7 genes were assigned to the CYP2C subfamily, which maps to human 10q24.1-q24.3 and mouse chromosome 19. Humans contain fewer genes in this cluster than do mice or rats. Four genes are arranged in the following order and orientation along human chromosome 10: RBP4, CYP2C18, CYP2C19/CYP2C9, and CYP2C8. The previsously identified CYP2C10 is an artifact of CYP2C9 and not a distinct isoform. All of the CYP2C proteins localize to the endoplasmic reticulum.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytochrome P450 Pan
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CYP2C9
Gene Accession No. P10632, P11712, P33260, P33261
Gene Alias Cytochrome P450 2C9, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, S-mephenytoin 4-hydroxylase, CYP2C9, CYP2C10, Cytochrome P450 2C8, CYPIIC8, Cytochrome P450 IIC2, Cytochrome P450 MP-12, Cytochrome P450 MP-20, Cytochrome P450 form 1, S-mephenytoin 4-hydroxylase, CYP2C8, Cytochrome P450 2C18, CYPIIC18, Cytochrome P450-6b/29c, CYP2C18, Cytochrome P450 2C19, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19
Gene Symbols CYP2C18, CYP2C19, CYP2C8, CYP2C9
Host Species Rabbit
Immunogen A synthetic peptide derived from the internal region of human Cytochrome P450 2C8/9/18/19
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1557, 1558, 1559, 1562
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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