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Invitrogen™ Cytokeratin 14 Polyclonal Antibody

Description
Recommended positive controls: HeLa, rat olfactory epithelium. Predicted reactivity: Mouse (95%), Rat (94%), Dog (96%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
Specifications
Specifications
| Antigen | Cytokeratin 14 |
| Applications | Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.51 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 20% glycerol and 0.025% ProClin 300; pH 7 |
| Gene | KRT14 |
| Gene Accession No. | P02533, Q6IFV1 |
| Gene Alias | AI626930; CK14; CK-14; cytokeratin 14; cytokeratin-14; EBS3; EBS4; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; Ka14; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 17; keratin-14; Koebner; Krt-1.14; Krt1-14; KRT14; LOC100737113; NFJ; Type I keratin Ka14 |
| Gene Symbols | KRT14 |
| Show More |
Safety and Handling
Product Identifier
- Cytokeratin 14 Polyclonal Antibody
- Warning
- Skin sensitiser Category 1
- H317-May cause an allergic skin reaction.
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P272-Contaminated work clothing should not be allowed out of the workplace.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
- MIXTURE LIST-Contain: Glycerin, 5-Chloro-2-methyl-3-isothiazolone, 2-Methyl-3-isothiazolone
Product Title
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