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Invitrogen™ DACH1 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA518909
This item is not returnable.
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Description
This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
Specifications
| DACH1 | |
| Polyclonal | |
| Unconjugated | |
| Dach1 | |
| Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1 | |
| Goat | |
| Ammonium sulfate precipitation | |
| RUO | |
| 1602 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.5 mg/mL | |
| TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
| Q9UI36 | |
| Dach1 | |
| Synthetic peptide sequence (SPVENTPQNNECK) corresponding to the internal amino acids of DACH1 (aa 177-190). | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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