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Invitrogen™ DACH1 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552968

Product Code. 15710921

  • € 568.00 / 100µL

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Description

Description

Immunogen sequence: PKRTQSVTSP ENSHIMPHSV PGLMSPGIIP PTGLTAAAAA AAAATNAAIA EAMKVKKIKL EAMSNYHASN NQHGADSENG DMNSSVGSSD GSWDKETLPS SPSQGPQASI THPRMPGARS LPLSHPLNHL QQSHLLPNGL ELP Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 88%.

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DACH1
Polyclonal
Unconjugated
Dach1
Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
Rabbit
Antigen affinity chromatography
RUO
1602
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
ChIP Assay, Immunohistochemistry (Paraffin), Immunocytochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9UI36
Dach1
Recombinant protein corresponding to Human DACH1. Recombinant protein control fragment (Product #RP-89667).
100 μL
Primary
Human
Antibody
IgG
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