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Invitrogen™ DAPK1 Monoclonal Antibody (12B2)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA534929
This item is not returnable.
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Description
Positive Control: Rat brain tissue, rat lung tissue, human lung cancer tissue, human skin tissue, mouse liver tissue.
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
Specifications
| DAPK1 | |
| Monoclonal | |
| 2 mg/mL | |
| PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
| P53355 | |
| DAPK1 | |
| Recombinant protein within Human DAP Kinase 1 aa 447-683. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| 12B2 | |
| Unconjugated | |
| DAPK1 | |
| D13Ucla1; DAP kinase 1; DAPK; DAPK1; DAP-Kinase; death associated protein kinase 1; death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 1612 | |
| -20°C, Avoid Freeze/Thaw Cycles, store in dark | |
| Liquid |
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