missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. 17961041

Invitrogen™ DARC Recombinant Mouse Monoclonal Antibody (2C3)
GREENER_CHOICE

Product Code. 17961041
Change view
Click to view available options
Quantity:
200 μg
Unit Size:
200µg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
17961041 200 μg 200µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 17961041 Supplier Invitrogen™ Supplier No. MA548104

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Mouse Recombinant Monoclonal Antibody

Specificity: The antibody binds specifcally to the pentapeptide FEDVW of the Duffy receptor.

ACKR1 or DARC is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades resulting instead in chemokine sequestration, degradation, or transcytosis. ACKR1 is also known as an interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. It has a promiscuous chemokine-binding profile by interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. ACKR1 also acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and for the malaria parasites P.vivax and P.knowlesi.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DARC
Applications ELISA, Flow Cytometry, Inhibition Assays
Classification Recombinant Monoclonal
Clone 2C3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene ACKR1
Gene Accession No. Q16570
Gene Alias AA162249; ACKR1; Atypical chemokine receptor 1; atypical chemokine receptor 1 (Duffy blood group); CCBP1; CD234; CD234 antigen; CTA-134P22.3; DARC; Dfy; Duffy Antigen; Duffy antigen chemokine receptor; Duffy antigen receptor for chemokines; duffy antigen/chemokine receptor; Duffy blood group antigen; duffy blood group chemokine receptor; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; ESTM35; FY; Fy Antigen; Fy glycoprotein; FYDuffy blood group; glycoprotein D; GPD; GPDWBCQ1; GpFy; HGNC:4035; OTTHUMP00000060081; Plasmodium vivax receptor; WBCQ1
Gene Symbols ACKR1
Host Species Mouse
Immunogen CHO cells transfected with cDNA encoding the Duffy glycoprotein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2532
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.