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Invitrogen™ DCC Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA585910
This item is not returnable.
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Description
DCC Polyclonal Antibody for Western Blot
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Specifications
| DCC | |
| Polyclonal | |
| Unconjugated | |
| DCC | |
| C030036D22Rik; Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; Dcc; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; tumor suppressor protein DCC | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 13176, 1630 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 0.2% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4 | |
| P43146, P70211 | |
| DCC | |
| Recombinant protein with of Human Netrin receptor DCC aa 21-299. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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