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DDB2 Monoclonal Antibody (OTI2E12), TrueMAB™, OriGene

Product Code. 17594124
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100 μL
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17594124 100 μL 100µL
17514134 30 μL 30µL
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Product Code. 17594124 Supplier Origene Technologies Supplier No. TA810712

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Description

Mouse Monoclonal Antibody

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.

Specifications

Antigen DDB2
Applications Western Blot
Classification Monoclonal
Clone OTI2E12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene DDB2
Gene Accession No. Q92466
Gene Alias DDBB, UV-DDB2, XPE
Gene Symbols DDB2
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-250 of human DDB2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1643
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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