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Invitrogen™ Dectin 1 (soluble) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA583996
This item is not returnable.
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Description
Immunogen sequence: DSSNELGFIV KQVSSQPDNS FWIGLSRPQT EVPWLWEDGS TFSSNLFQIR TTATQENPSP NCVWIHVSVI YDQLCSVPSY SICEKKFS Highest antigen sequence indentity to the following orthologs: Mouse - 35%, Rat - 56%.
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
Specifications
| Dectin 1 (soluble) | |
| Polyclonal | |
| Unconjugated | |
| Clec7a | |
| Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 64581 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot, Immunocytochemistry, Western Blot | |
| 0.05 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9BXN2 | |
| Clec7a | |
| Recombinant protein corresponding to Human CLEC7A. Recombinant protein control fragment (Product #RP-104894). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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