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Invitrogen™ DERL1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA116598
This item is not returnable.
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Description
This antibody is predicted to react with xenopus, bovine, chicken, rat, zebrafish, and mouse based on 100% sequence homology. Suggested positive control: antigen standard for DERL1 (transient overexpression lysate), KRM (canine microsome) lysates.
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Specifications
| DERL1 | |
| Polyclonal | |
| Unconjugated | |
| DERL1 | |
| 1110021N07Rik; AI195141; AW551338; Degradation in endoplasmic reticulum protein 1; DER1; DER-1; Der1-like domain family, member 1; der1-like protein 1; Derl1; derlin 1; derlin-1; DERtrin-1; RGD1311835; UNQ243/PRO276 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 103158862, 475086, 67819, 79139 | |
| 4°C, do not freeze | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| Phosphate, tris citrate with 0.1% sodium azide; pH 7-8 | |
| Q99J56, Q9BUN8 | |
| DERL1 | |
| A synthetic peptide made to the C-terminal region of human Derlin 1 (between residues 200-251). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Canine, Hamster | |
| Antibody | |
| IgG |
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