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Invitrogen™ DERL2 Polyclonal Antibody
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Product Code. 17267873 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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17267873 100 μL 100µL
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Product Code. 17267873 Supplier Invitrogen™ Supplier No. PA5115111

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DERL2.

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DERL2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene DERL2
Gene Accession No. Q8BNI4, Q9GZP9
Gene Alias carcinoma related; CGI-101; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; der1-like protein 2; Der2; Derl2; derlin 2; derlin-2; derlin-2-like; DERtrin-2; F-LAN-1; Flana; F-LANa; LOC100910823; SBBI53
Gene Symbols DERL2
Host Species Rabbit
Immunogen A synthesized peptide derived from human DERL2(Accession Q9GZP9), corresponding to amino acid residues P193-G239.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100910823, 116891, 51009
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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