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Invitrogen™ Desmoglein 3 Polyclonal Antibody
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Product Code. 30534297
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Quantity:
100 μg
Unit Size:
100µg
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30534297 100 μg 100µg
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Product Code. 30534297 Supplier Invitrogen™ Supplier No. PA5148527

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Description

Goat Polyclonal Antibody

Reconstitute at 0.2 mg/mL in sterile PBS.

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmoglein 3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with trehalose and no preservative
Gene Dsg3
Gene Accession No. P32926
Gene Alias 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA
Gene Symbols Dsg3
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human Desmoglein-3, Glu50-Arg615.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1830
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG
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