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Invitrogen™ DIABLO Recombinant Rabbit Monoclonal Antibody (0W1K4)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA538181
This item is not returnable.
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Description
Positive Samples: SP2/0, HeLa, MCF7, C2C12, Jurkat, C6, Mouse heart, Rat lung, Rat testis Immunogen sequence: AVPIAQKSEP HSLSSEALMR RAVSLVTDST STFLSQTTYA LIEAITEYTK AVYTLTSLYR QYTSLLGKMN SEEEDEVWQV IIGARAEMTS KHQEYLKLET TWMTAVGLSE MAAEAAYQTG ADQASITARN HIQLVKLQVE EVHQLSRKAE TKLAEAQIEE LRQKTQEEGE ERAESEQEAY LRED.
DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
Specifications
| DIABLO | |
| Recombinant Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| Q9JIQ3, Q9NR28 | |
| DIABLO | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_0639401). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0W1K4 | |
| Unconjugated | |
| DIABLO | |
| 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 288753, 56616, 66593 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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