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Invitrogen™ Human DIABLO/SMAC ELISA Kit

Product Code. 17757913
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Quantity:
10 x 96 Tests
Unit Size:
Pack of 10
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17757913 10 x 96 Tests Pack of 10
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Product Code. 17757913 Supplier Invitrogen™ Supplier No. EHDIABLOX10

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Description

ELISA

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NR28
Assay Range 0.12 to 30 ng/mL
Assay Sensitivity 100 pg/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum, Supernatant
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 56616
Gene Symbol DIABLO
Interassay CV <12%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Label or Dye HRP
Quantity 10 x 96 Tests
Regulatory Status RUO
Sample Volume Plasma 50 μL, Serum 50 μL, Supernatant 100 μL
Storage Requirements 2°C to 8°C
Target SMAC
Test Time 1 hrs 20 mins
Total Assay Time 4 hrs 45 mins
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