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DIS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16843454 Shop All Proteintech Products
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150 μL
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20µL
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16843454 20 μL 20µL
16833454 150 μL 150µL
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Product Code. 16843454 Supplier Proteintech Supplier No. 146891AP20UL

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Description

Rabbit Polyclonal Antibody

The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

Specifications

Antigen DIS3
Applications Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DIS3
Gene Accession No. Q9CSH3, Q9Y2L1
Gene Alias DIS3, dis3p, EXOSC11, KIAA1008, Protein DIS3 homolog, RP11 342J4.3, RRP44
Gene Symbols Dis3
Host Species Rabbit
Immunogen DIS3 Fusion Protein Ag6117
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22894, 306103, 72662
Target Species Human, Rat, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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