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Invitrogen™ DNMBP Monoclonal Antibody (1H2)
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Product Code. 15509002
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
15509002 100 μg 100µg
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Product Code. 15509002 Supplier Invitrogen™ Supplier No. MA521436

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Description

Mouse Monoclonal Antibody

Peptide Sequence: TKKPFERKTI DRQSARKPLL GLPSYMLQSE ELRASLLARY PPEKLFQAER NFNAAQDLDV SLLEGDLVGV IKKKDPMGSQ NRWLIDNGVT KGFVYSSFLK.

The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNMBP
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1H2
Concentration 0.2-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene DNMBP
Gene Accession No. Q6XZF7
Gene Alias 2410003L07Rik; 2410003M15Rik; ARHGEF36; Dnmbp; dynamin binding protein; dynamin-binding protein; Kiaa1010; Scaffold protein Tuba; TUBA
Gene Symbols DNMBP
Host Species Mouse
Immunogen DNMBP (AAH41628, 491 a.a. ~ 590 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23268
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG3 κ
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