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DNMT3B Mouse anti-Human, Clone:4D1A2E5, Abnova™
Mouse monoclonal antibody raised against recombinant human DNMT3B.
Brand: Abnova MAB17124.100ug
This item is not returnable.
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Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq]Specifications
| DNMT3B | |
| Monoclonal | |
| Unconjugated | |
| ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry Immunocytochemistry (1:200-1:1000) Flow Cytometry (1:200-1:400 The optimal working dilution should be determined by the end user. |
|
| DNMT3B | |
| Mouse | |
| 100 μg | |
| Human | |
| Antibody | |
| IgG2a |
| ELISA, Flow Cytometry, Immunocytochemistry, Western Blot | |
| 4D1A2E5 | |
| DNA (cytosine-5-)-methyltransferase 3 beta | |
| In PBS (0.05% sodium azide) | |
| ICF, M.HsaIIIB | |
| Recombinant protein corresponding to amino acid 1-150 of human DNMT3B from E. coli. | |
| 1789 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| Liquid |
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