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DOK2 Mouse anti-Human, Clone: OTI1G9, lyophilized, TrueMAB™

Product Code. 17643041
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Quantity:
100 μg
Unit Size:
100µg
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17643041 100 μg 100µg
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Product Code. 17643041 Supplier Origene Technologies Supplier No. CF503303

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Specifications

Antigen DOK2
Applications Western Blot
Classification Monoclonal
Clone OTI1G9
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene DOK2
Gene Accession No. O60496
Gene Alias p56DOK, p56dok-2
Gene Symbols DOK2
Host Species Mouse
Immunogen Full length human recombit protein of human DOK2 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9046
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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