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Invitrogen™ DTX3L Monoclonal Antibody (K24022_12C6), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA555814
This item is not returnable.
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Description
Sequence of this protein is as follows: RVRRKLESYF QSSKSSGGGE CTVSTQEHEA PGTFRVEFSE RAAKERVLKK GEHQILVDEK PVPIFLVPTE NSIKKNTRPQ ISSLTQSQAE TPSGDMHQHE
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Specifications
| DTX3L | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide | |
| Q8TDB6 | |
| DTX3L | |
| Recombinant human DTX3L (immunogen range is 21-120). | |
| 50 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| K24022_12C6 | |
| Unconjugated | |
| DTX3L | |
| AU042200; Bbap; BC023741; B-lymphoma- and BAL-associated protein; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; deltex 3-like (Drosophila); deltex E3 ubiquitin ligase 3L; DTX3L; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; RGD1565144; rhysin 2; Rhysin2; rhysin-2; RING-type E3 ubiquitin transferase DTX3L | |
| Mouse | |
| Protein A | |
| RUO | |
| 151636 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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