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DYRK2 Monoclonal Antibody (OTI1G8), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA810286
This item is not returnable.
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Description
DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.Specifications
| DYRK2 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q92630 | |
| DYRK2 | |
| Human recombit protein fragment corresponding to amino acids 1-210 of human DYRK2 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI1G8 | |
| Unconjugated | |
| DYRK2 | |
| dual specificity tyrosine phosphorylation regulated kinase 2 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 8445 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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