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Invitrogen™ ECD Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA581542

Product Code. 16348554

  • € 341.00 / 100µL

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Description

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Mouse ECD.

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ECD
Polyclonal
Unconjugated
ECD
5730461K03Rik; Ecd; ecdysoneless cell cycle regulator; ecdysoneless homolog; ecdysoneless homolog (Drosophila); GCR2; HSGT1; Human suppressor of GCR two; protein ecdysoneless homolog; protein SGT1; protein SGT1 homolog; SGT1; SGT1 protein; suppressor of GCR2; suppressor of S. cerevisiae gcr2
Rabbit
Antigen affinity chromatography, Protein A
RUO
70601
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
1 mg/mL
PBS with no preservative
Q9CS74
ECD
A synthetic peptide corresponding to the center region of the Mouse ECD/Ecdysoneless homolog.
100 μL
Primary
Mouse
Antibody
IgG
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