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Invitrogen™ EFCAB4B Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA585460
This item is not returnable.
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Description
Keep as concentrated solution. Positive Control: A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Specifications
| EFCAB4B | |
| Polyclonal | |
| Unconjugated | |
| Cracr2a | |
| Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release activated channel regulator 2A; calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; Cracr2a; Efcab4b; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Gm1073; Gm462; RGD1563719 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 84766 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.56 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q9BSW2 | |
| Cracr2a | |
| Recombinant protein encompassing a sequence within the center region of human EFCAB4B. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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