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Invitrogen™ Human EGFR (ErbB1) [L858R], GST Tag Recombinant Protein

Product Code. 11583617
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Quantity:
10 μg
Unit Size:
10µg
This item is not returnable. View return policy

Product Code. 11583617

Brand: Invitrogen™ PV4128

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This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P00533
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Gene ID (Entrez) 1956
Molecular Weight (g/mol) 90.5 kDa
Name Human EGFR (ErbB1) [L858R], GST Tag
Quantity 10 μg
Regulatory Status For research use only. Not for use in diagnostic procedures
Gene Alias EGFR; Erbb1
Common Name EGFR (L858R Mutant)
KinaseFamily EGF receptor (ErbB)
Protein Length 668-1210: L858R
Product Type EGFR (ErbB1) [L858R] Recombinant Human Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Insect cells
Protein Family Kinase and inhibitors
Form Liquid
Protein Subtype Receptor tyrosine kinases
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