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Invitrogen™ EGLN1/EGLN2 Polyclonal Antibody
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Product Code. 17197603
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Quantity:
100 μL
Unit Size:
100µL
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17197603 100 μL 100µL
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Product Code. 17197603 Supplier Invitrogen™ Supplier No. PA5109677

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DIRGDKITWI EGKEPGCETI GLLMSSMDDL IRHCNGKLGS YKINGRTKAM VACYPGNGTG YVRHVDNPNG DGRCVTCIYY LNKDWDAKVS GGILRIFPEG K.

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EGLN1/EGLN2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.81 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Egln1
Gene Accession No. Q96KS0, Q9GZT9
Gene Alias 0610011A13Rik; AI503754; C1orf12; C85656; ECYT3; egl nine homolog 1; Egl nine homolog 2; egl nine-like protein 1; egl-9 family hypoxia inducible factor 1; egl-9 family hypoxia inducible factor 2; egl-9 family hypoxia-inducible factor 1; egl-9 family hypoxia-inducible factor 2; EGLN1; EGLN2; EIT6; EIT-6; Estrogen-induced tag 6; falkor; HALAH; HIF prolyl hydroxylase 2; HIF-1alpha prolyl-4-hydroxylase-1; Hif-p4h-1; Hif-p4h-2; HIFPH1; HIF-PH1; HIFPH2; HIF-PH2; HIF-prolyl hydroxylase 1; HIF-prolyl hydroxylase 2; HPH-1; HPH2; HPH-2; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase 2; Ier4; immediate early response 4; ORF13; PHD1; PHD-1; PHD2; PHD-2; PNAS-118; PNAS-137; Prolyl hydroxylase domain-containing protein 1; prolyl hydroxylase domain-containing protein 2; SM20; SM-20; zinc finger MYND domain-containing protein 6; ZMYND6
Gene Symbols Egln1, EGLN2
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112398, 54583
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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