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EOMES Monoclonal Antibody (21Mags8), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-4876-80
Additional Details : Weight : 0.01000kg
Description
Description: This 21Mags8 antibody recognizes Eomesodermin (Eomes), also known as T-box brain 2 (TBR2). Eomes is a T-box transcription factor that is highly homologous to T-bet, which is essential during trophoblast development and gastrulation in most vertebrates. In the immune system, Eomes controls the differentiation of effector and memory CD8+ T cells, as well as natural killer (NK) cells. Expression of Eomes in these cells correlates with high expression of CD122, the common beta-chain of the IL-2R and IL-15R. Note: For detection of mouse Eomes, we recommend 12-4875 and 51-4875 and for detection of human Eomes, we recommend 51-4877 due to the brighter staining intensity of these products compared to clone 21Mags8. Applications Reported: This 21Mags8 antibody has been reported for use in flow cytometric analysis, and immunoblotting (WB). Applications Tested: This 21Mags8 antibody has been tested by western blot analysis of mouse splenocytes. As a starting concentration, this antibody can be used at 2 µg/mL. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
TBR2 is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation. TBR2 plays a role in brain development and is required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex.Specifications
EOMES | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
O54839, O95936 | |
Eomes | |
Affinity chromatography | |
RUO | |
13813, 8320 | |
4° C | |
Liquid |
Flow Cytometry, Western Blot | |
21Mags8 | |
Unconjugated | |
Eomes | |
C77258; EOMES; eomesodermin; eomesodermin homolog; eomesodermin homolog (Xenopus laevis); T-box brain protein 2; T-box transcription factor; TBR2; TBR-2; T-brain-2 | |
Rat | |
25 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG2a κ |
For Research Use Only.