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Invitrogen™ EpCAM (CD326) Recombinant Rabbit Monoclonal Antibody (BLR077G)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA544345
This item is not returnable.
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Description
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
Specifications
| EpCAM (CD326) | |
| Recombinant Monoclonal | |
| 0.5 mg/mL | |
| BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6 | |
| P16422 | |
| EPCAM | |
| Peptide representing a region between residue 264 and the C-terminus (residue 314) of human Epithelial cell adhesion molecule. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| BLR077G | |
| Unconjugated | |
| EPCAM | |
| adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1 | |
| Rabbit | |
| purified | |
| RUO | |
| 4072 | |
| 4°C | |
| Liquid |
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