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Invitrogen™ EpoR Monoclonal Antibody (38409)

Product Code. 15573512
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Quantity:
100 μg
Unit Size:
100µg
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15573512 100 μg 100µg
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Product Code. 15573512 Supplier Invitrogen™ Supplier No. MA523824

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Description

Mouse Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant mouse Erythropoietin R is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

EpoR encodes the erythropoietin receptor, which belongs to the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which in turn activates various intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. The stimulated erythropoietin receptor plays a role in the survival of erythroid cells. Defects in this gene may result in erythroleukemia and familial erythrocytosis. Dysregulation of this gene may also affect the growth of certain tumors. Multiple transcript variants are produced as a result of alternate splicing. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EpoR
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 38409
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene EPOR
Gene Accession No. P19235
Gene Alias EPO R; EPOR; EPO-R; Erythropoietin receptor; pEpoR
Gene Symbols EPOR
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human Erythropoietin R Pro26-Pro250.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2057
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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