missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ ERLIN2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA551669
This item is not returnable.
View return policy
Description
Immunogen sequence: KTKLLIAAQK QKVVEKEAET ERKKALIEAE KVAQVAEITY GQKVMEKETE KKISEIEDAA FLAREKAKAD AECYTAMKIA EANKLKLTPE YLQLMKYKAI ASNSKIYFGK DIPNMFMDSA GSVSKQFEGL ADKLSFGLED EPLETATK Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
Specifications
| ERLIN2 | |
| Polyclonal | |
| Unconjugated | |
| ERLIN2 | |
| BC036333; C87251; C8orf2; EMBL:AAI68668.1, ECO:0000312; EMBL:AAI68668.1}; endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250; ER lipid raft associated 2; Erlin2; erlin-2; erlin-2 {ECO:0000250; erlin2 {ECO:0000312; HGNC:1356; MGC87072; NET32; RGD:1309010}; RGD1309010; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250; Spfh2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250; UniProtKB:Q8BFZ9, ECO:0000312; UniProtKB:Q8BFZ9}; UNQ2441; UNQ2441/PRO5003/PRO9924 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 11160, 244373, 290823 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.3 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| B5DEH2, O94905, Q8BFZ9 | |
| ERLIN2 | |
| Recombinant protein corresponding to Human ERLIN2. Recombinant protein control fragment (Product #RP-95924). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction