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ETS1 associated protein II Antibody (TDP2/1258), PE, Novus Biologicals™
Mouse Monoclonal Antibody
Brand: Novus Biologicals NBP2-50071PE
This item is not returnable.
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Description
ETS1 associated protein II Monoclonal specifically detects ETS1 associated protein II in Human samples. It is validated for Flow Cytometry.
Specifications
| ETS1 associated protein II | |
| Monoclonal | |
| PE | |
| PBS with 0.05% Sodium Azide | |
| TDP2 | |
| Recombinant full-length human ETS1 associated protein II protein (Uniprot: O95551) | |
| 0.1 mL | |
| Signal Transduction, Transcription Factors and Regulators | |
| This MAb recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation. | |
| Store at 4°C in the dark. |
| Flow Cytometry | |
| TDP2/1258 | |
| Flow Cytometry | |
| AD022, dJ30M3.3, EAP2, EAPII, EC 3.1.4.-, ETS1-associated protein 2, ETS1-associated protein II, MGC111021,5'-Tyr-DNA phosphodiesterase, MGC9099,5'-tyrosyl-DNA phosphodiesterase, TRAF and TNF receptor associated protein, TTRAPTRAF and TNF receptor-associated protein, Tyr-DNA phosphodiesterase 2, tyrosyl-DNA phosphodiesterase 2 | |
| Mouse | |
| Protein A or G purified | |
| RUO | |
| Primary | |
| Human | |
| IgG2b κ |
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