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  6. Invitrogen™ Ezabenlimab Recombinant Monoclonal Antibody

Invitrogen™ Ezabenlimab Recombinant Monoclonal Antibody
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Product Code. p-200111863
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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Product Code. Quantity unitSize
30283839 100 μg 100µg
30283794 1 mg 1mg
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Product Code. 30283839 Supplier Invitrogen™ Supplier No. MA559715

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Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Ezabenlimab, also known as BI 754091, is a humanized monoclonal antibody that targets the programmed cell death protein 1 (PD-1). The gene PDCD1, also known as PD-1 or CD279, encodes Programmed Cell Death Protein 1, a crucial immune checkpoint receptor expressed on T cells and other immune cells. Located on chromosome 2q37.3, PDCD1 consists of five exons. PD-1 is a type I transmembrane protein within the CD28/CTLA-4 superfamily and functions primarily to inhibit immune responses, thus maintaining peripheral tolerance and preventing autoimmune reactions. Upon binding to its ligands, PD-L1 and PD-L2, expressed on tumor cells and other tissues, PD-1 mediates the suppression of T-cell activity, inducing apoptosis in antigen-specific T cells while sparing regulatory T cells, contributing significantly to immune evasion by tumors.
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Specifications

Antigen Ezabenlimab Humanized
Applications ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
Classification Recombinant Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
Host Species Human
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG4SP
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