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Invitrogen™ FAM35A/FAM35B Polyclonal Antibody
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Product Code. 16690825 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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16690825 100 μL 100µL
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Product Code. 16690825 Supplier Invitrogen™ Supplier No. PA5104378

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total FAM35A/B.

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen FAM35A/FAM35B
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FAM35A
Gene Accession No. Q86V20
Gene Alias 3110001K24Rik; bA163M19.1; Fam35a; FAM35A1; family with sequence similarity 35 member A; family with sequence similarity 35, member A; protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2; RINN2; Shield complex subunit 2; Shieldin complex subunit 2; SHLD2
Gene Symbols FAM35A
Host Species Rabbit
Immunogen A synthesized peptide derived from human FAM35A(Accession Q86V20), corresponding to amino acid residues S393-N443.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54537
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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