Invitrogen™ FARSA Polyclonal Antibody

Description

Immunogen sequence: EVIEAELRST KHWELTAEGE EIAREGSHEA RVFRSIPPEG LAQSELMRLP SGKVGFSKAM SNKWIRVDKS AADGPRVFRV VDSMEDEVQR RLQLVRGGQA EKLGEKERSE LRKRKLLAEV TLKTYWVSKG Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. FARS2 is a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. FARS1 encodes a mitochondrially-located phenylalanine-tRNA synthetase (PheRS) which consists of a single polypeptide chain unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and the eukaryotic cytoplasm.