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Invitrogen™ FBXW7 Polyclonal Antibody

Product Code. 13237248
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Quantity:
100 μg
Unit Size:
100µg
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13237248 100 μg 100µg
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Product Code. 13237248 Supplier Invitrogen™ Supplier No. PA522805

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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for FBXW7 (transient overexpression lysate).

F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FBXW7
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FBXW7
Gene Accession No. Q969H0
Gene Alias 1110001A17Rik; AGO; archipelago; Archipelago homolog; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein FBX30; F-box protein Fbxw6; F-box protein SEL-10; F-box/WD repeat-containing protein 7; F-box-WD40 repeat protein 6; FBW6; FBW7; Fbwd6; FBX30; Fbxo30; FBXW6; FBXW7; FLJ11071; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL10; SEL-10
Gene Symbols FBXW7
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the N terminus of the 69 kDa isoform of the hCdc4 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55294
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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