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Fenebrutinib, MedChemExpress

Product Code. 16490398
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Product Code. 16490398

Brand: Medchem Express HY19834

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Description

MedChemExpress Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with Kis of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research.

Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with Kis of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research.

Specifications

Chemical Name or Material Fenebrutinib
CAS 1434048-34-6
Color Off-White
Purity Grade Notes Research
Molecular Formula C37H44N8O4
Quantity 5 mg
Synonym GDC-0853
Solubility Information DMSO : ≥ 23 mg/mL (34.60 mM)
SMILES O=C1C(NC(C=C2)=NC=C2N3CCN(C4COC4)C[C@@H]3C)=CC(C5=CC=NC(N6C(C7=CC(CC(C)(C)C8)=C8N7CC6)=O)=C5CO)=CN1C
Molecular Weight (g/mol) 664.8
Formula Weight 664.8
Percent Purity 98.06%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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